Effects of PlasmaTreatmentwith PurifiedProteinA and Staphylococcus aureusCowan I on SpontaneousAnimalNeoplasms1
نویسندگان
چکیده
Eleven dogs with spontaneous neoplasms were Intensively treated with an ¡mmunoadsorption system consisting of a contin uous flow centrifuge, Protein A-Sepharose columns, and a semi automatic elution system. Despite consistent and substantial lowering of immunoglobulin G levels, tumor regression was noted in only one of 11 dogs. In contrast, infusion of small volumes of plasma after incubation with heat and formalin-treated Staphy lococcus aureus Cowan I resulted in a tumoricidal response in five of six animals. These results suggest that tumor necrosis is probably not induced by Protein A-mediated removal of humoral "blocking" factors.
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